Open hundreds of cards, upgrade your deck, and claw your way to the top of the food chain
The other option is to take advantage of the direct damage, which is good in its own right to either finish off a damaged character or get them within range to be banished but also works with the likes of cards that benefit from being damaged - such as Scroop, Backstabber - that benefit from healing damage, like Rapunzel, Gifted Artist, or from damage being dealt: like Beast, Relentless.
These kinds of cards will almost always be your best bet here
It is the first ever Lorcana card released, given out a year before the first set even came out at D23 in 2022
Ripples of Potential This is very similar in concept to Mutational Advantage, but its cheaper and in one color, and phasing is better protection in most cases
However, I think now may be a good time for the Princesses to shine in all their glory considering the new Princess cards released in Fabled and the loss of strong removal in the upcoming meta due to the Set Rotation